Term | Value | Language |
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dc.contributor.advisor | Hutchison, James | |
dc.contributor.author | Ginzburg, Aurora | |
dc.date.accessioned | 2020-02-27T21:29:26Z | |
dc.date.issued | 2020-02-27 | |
dc.identifier.uri | https://scholarsbank.uoregon.edu/xmlui/handle/1794/25217 | |
dc.description.abstract | The success of sustainable products in commerce relies on enhancing performance while minimizing environmental impacts. Avoiding the selection of alternatives that have unrealized negative consequences is of the utmost importance. Achieving these goals relies on understanding the fundamental relationships between material structure, function, and toxicity. Since innovation is often needed to access viable alternatives, novel materials that have established and controllable underlying chemistries are the most beneficial for preparing alternatives with desired properties. Nanomaterials are promising candidates for revolutionizing many technologies; they can impart sophisticated functionality with minimal material. However, they haven’t seen widespread commercialization due to various roadblocks in harnessing their potential. Advances in synthetic and analytical methods that allow for rapid iteration and screening are poised to alleviate some of these challenges. This dissertation focuses on the development of adaptable synthetic methods to generate well-defined nanoparticles capable of fulfilling commercial needs. This dissertation first introduces sustainable product design, particularly as it pertains to the development of nanomaterials. The synthetic and characterization challenges faced at the nanoscale are highlighted, followed by advances in adaptable syntheses and high-throughput analysis. Additionally, the importance of evaluating nanomaterial performance and safety in environments representative of their commercial use is discussed. The following two chapters present novel single-step syntheses for accessing mixed-ligand gold nanoparticles with well-defined and tunable structures. The first study accesses gold nanoparticles that act analogously to traditional molecular reagents because of their clickable ligand shell, and the second study accesses partially cationic gold nanoparticles that have significantly reduced toxicity compared to nanoparticles with entirely cationic shells. The following two chapters demonstrate the importance of evaluating nanoparticle safety in formulas. The first study shows that a synergistic toxicity is produced by combining food-grade surfactants and non-toxic gold nanoparticles, and the second study shows that zinc oxide particles induce sunscreen toxicity upon UV irradiation. Finally, the last chapter of this dissertation presents a framework for teaching chemistry students to design sustainable products that offer both environmental and performance benefits. This dissertation includes previously published and unpublished co-authored material. | en_US |
dc.language.iso | en_US | |
dc.publisher | University of Oregon | |
dc.rights | All Rights Reserved. | |
dc.subject | green chemistry | en_US |
dc.subject | mixed-ligand nanoparticles | en_US |
dc.subject | mixture effects | en_US |
dc.subject | mixture toxicity | en_US |
dc.subject | nanotoxicology | en_US |
dc.subject | systems thinking | en_US |
dc.title | Toward Safer, High-Performing Products Using Well-Defined Nanoparticles and Deliberate Formulations | |
dc.type | Electronic Thesis or Dissertation | |
dc.description.embargo | 2020-10-16 | |
thesis.degree.name | Ph.D. | |
thesis.degree.level | doctoral | |
thesis.degree.discipline | Department of Chemistry and Biochemistry | |
thesis.degree.grantor | University of Oregon |